Evidence-Based Treatments for Androgenetic Alopecia (Female and Male Pattern Hair Loss) in the UK
Androgenetic alopecia (AGA), commonly referred to as male and female pattern baldness, is a prevalent form of hair loss affecting both genders. In the UK, various treatments have been rigorously studied for their effectiveness in managing AGA. Here are some of the most scientifically supported options:
1. 5-α Reductase Inhibitors:
Medications like finasteride and dutasteride are commonly prescribed for AGA. These inhibitors work by blocking the enzyme 5-α reductase, which plays a role in converting testosterone to dihydrotestosterone (DHT), a hormone linked to hair follicle miniaturisation. Finasteride, in particular, is FDA-approved for male AGA. However, it’s essential to consider potential adverse effects, as indicated in studies (Alkahtane et al., 2019).
2. Topical Minoxidil:
Topical minoxidil, especially in a 5% formulation, is widely used for AGA treatment. It stimulates hair follicles and prolongs the growth phase of the hair cycle. Notably, 5% minoxidil is the only FDA-approved treatment for female AGA. Research suggests that intradermal injections of 0.5% minoxidil can be more effective than a placebo for female AGA (Pietrauszka & Bergler-Czop, 2022; Uzel et al., 2020).
3. Platelet-Rich Plasma (PRP) Therapy:
PRP therapy involves injecting plasma enriched with growth factors into the scalp to promote hair growth and improve density. Studies have examined its safety and efficacy in both male and female AGA cases (Mercuri et al., 2021; Gkini et al., 2014). Combining PRP therapy with other treatments like micro-needling and background therapy has also shown promise (Bhoite et al., 2022).
4. Low-Level Light Therapy (LLLT):
Utilising devices such as helmet-type devices, LLLT stimulates hair follicles with low-level lasers or LEDs, encouraging hair growth. This non-invasive approach has gained FDA approval for AGA treatment and has demonstrated effectiveness in various studies (Yoon et al., 2020; Ryu et al., 2023).
5. Seeking a Trichologist:
Considering the complexity of AGA and the range of available treatments, consulting with an evidence-based trichologist is crucial. A trichologist grounded in scientific evidence can provide personalised recommendations based on the latest research findings, helping patients navigate their treatment options effectively.
In conclusion, evidence-based treatments like 5-α reductase inhibitors, topical minoxidil, PRP therapy, and LLLT offer viable solutions for managing AGA in the UK. However, it’s essential to consult with a trichologist who prioritises scientific evidence to ensure the most suitable treatment approach for each individual.
If you’re experiencing hair loss, consider consulting with an evidence-based trichologist who can offer personalised treatment recommendations tailored to your specific needs. With the right treatment plan, you can take steps towards regaining confidence in your hair and overall appearance.
Contact CliniHair
If you have any questions or concerns regarding your hair loss, please don’t hesitate to reach out via email at [email protected]. Our dedicated trichologist is here to provide you with the support you need.
References included to maintain credibility and transparency.
Alkahtane, A., Albasher, G., Alsultan, N., Al-Qahtani, W., Alarifi, S., Almeer, R., … & Alkahtani, S. (2019). Long-term treatment with finasteride induces apoptosis and pathological changes in female mice. Human & Experimental Toxicology, 38(7), 762-774.
https://doi.org/10.1177/0960327119842195 Bhoite, K., Chikhalkar, S., Mishra, S., & Kharkar, V. (2022). Injectable platelet rich fibrin therapy for androgenetic alopecia: a series of 15 cases. International Journal of Research in Dermatology, 8(4), 398.
https://doi.org/10.18203/issn.2455-4529.intjresdermatol20221637 Gkini, M., Kouskoukis, A., Tripsianis, G., Rigopoulos, D., & Kouskoukis, K. (2014). Study of platelet-rich plasma injections in the treatment of androgenetic alopecia through an one-year period. Journal of Cutaneous and Aesthetic Surgery, 7(4), 213. https://doi.org/10.4103/0974-2077.150743
Khattab, F. and Bessar, H. (2019). Accelerated hair growth by combining thread monofilament and minoxidil in female androgenetic alopecia. Journal of Cosmetic Dermatology, 19(7), 1738-1744. https://doi.org/10.1111/jocd.13228
Mercuri, S., Paolino, G., Nicola, M., & Vollono, L. (2021). Investigating the safety and efficacy of platelet-rich plasma (prp) treatment for female androgenetic alopecia: review of the literature. Medicina, 57(4), 311. https://doi.org/10.3390/medicina57040311
Pietrauszka, K. and Bergler-Czop, B. (2022). Sulfotransferase sult1a1 activity in hair follicle, a prognostic marker of response to the minoxidil treatment in patients with androgenetic alopecia: a review. Advances in Dermatology and Allergology, 39(3), 472-478.https://doi.org/10.5114/ada.2020.99947
Ryu, H., Abueva, C., Padalhin, A., Chung, P., & Woo, S. (2023). Low-level laser therapy in androgenetic alopecia: narrative review. Medical Lasers, 12(1), 11-17. https://doi.org/10.25289/ml.23.008
Uzel, B., Takano, G., Chartuni, J., Cesetti, M., Gavioli, C., Lemes, A., … & Costa, I. (2020). Intradermal injections with 0.5% minoxidil for the treatment of female androgenetic alopecia: a randomized, placebo‐controlled trial. Dermatologic Therapy, 34(1). https://doi.org/10.1111/dth.14622
Yoon, J., Ku, W., Lee, J., & Ahn, H. (2020). Low-level light therapy using a helmet-type device for the treatment of androgenetic alopecia. Medicine, 99(29), e21181. https://doi.org/10.1097/md.0000000000021181